Protocol Status: PUBLISHED
Protocol:
Version: 2026.01
Effective Date:
Last Reviewed:
Medical Director Approval:
Clinical Note: This content reflects current GCEMS clinical guidelines as of the dates listed above. If content appears inconsistent with current policy, use the most recent approved guideline and notify leadership for correction.

Amiodarone

(Cordarone)

 

Indications:

 

  • Shock resistant V-fib or pulseless V-Tac, Unstable V-Tach

 

Contraindications:

 

  • Hypersensitivity to any of the contents
  • Unmanaged cardiogenic shock
  • Marked sinus bradycardia
  • 2nd or 3rd degree AV blocks

 

Side Effects:

 

  • Hypotension, bradycardia, AV block, asystole, PEA, hypertoxicity

 

ADULT

 

Pulseless VF/VT:

 

  • 300mg IV/IO bolus; repeat once at 150mg IV/IO bolus

 

VT with pulse:

 

  • 150mg in 50mL NS or D5W administered through a 10 gtt set over 10 minutes.
  • May repeat once if patient remains in unstable VT to a total dose of 300mg over 20 minutes.

 

Maintenance Drip:

 

  • 1mg/minute = 150mg in 50 mL NS or D5, administered through a 60 gtt set at 20 gtts per minute.

 

PEDIATRIC

 

Pulseless VF/VT:

 

  • 5mg/kg IV/IO bolus

 

Termination of VF/VT:

 

  • 5mg/kg IV/IO over 20 minutes
  • Place amount of medication in 50 mL of NS or D5W, administered through a 10 gtt set over 20 minutes.
  • Repeat doses of 5mg/kg IV/IO over 20 minutes; maximum 15mg/kg