Amiodarone (Cordarone)

 

Indications:

 

  • Shock resistant V-fib or pulseless V-Tac, Unstable V-Tach

 

  • Contraindications:

 

    • Hypersensitivity to any of the contents
    • Unmanaged cardiogenic shock
    • Marked sinus bradycardia
    • 2nd or 3rd degree AV blocks

 

Side Effects:

 

  • Hypotension, bradycardia, AV block, asystole, PEA, hypertoxicity

 

ADULT

 

Pulseless VF/VT:

 

  • 300mg IV/IO bolus; repeat once at 150mg IV/IO bolus

 

VT with pulse:

 

  • 150mg in 50mL NS or D5W administered through a 10 gtt set over 10 minutes.
  • May repeat once if patient remains in unstable VT to a total dose of 300mg over 20 minutes.

 

Maintenance Drip:

 

  • 1mg/minute = 150mg in 50 mL NS or D5, administered through a 60 gtt set at 20 gtts per minute.

 

PEDIATRIC

 

Pulseless VF/VT:

 

  • 5mg/kg IV/IO bolus

 

Termination of VF/VT:

 

  • 5mg/kg IV/IO over 20 minutes
  • Place amount of medication in 50 mL of NS or D5W, administered through a 10 gtt set over 20 minutes.
  • Repeat doses of 5mg/kg IV/IO over 20 minutes; maximum 15mg/kg