AMYL NITRITE

(Special Purpose: Toxicology)

 

  • INDICATIONS:

 

    • Cyanide Poisoning

 

 

  • ADMINISTRATION:

 

    • Inhalation  only

 

 

  • DOSAGE:

 

    • ADULT:

 

      • One or two inhalants of amyl nitrite should be crushed and inhaled for 15 to 30  seconds.

 

    • PEDIATRIC:

 

      • One inhalant should be crushed and inhaled for 15 to 30 seconds. (Smallest effective dosage should be used.)

 

 

 

  • THERAPEUTIC EFFECTS:

 

    • It is effective in the emergency management  of cyanide poisoning.
    • Amyl nitrite causes the oxidation of hemoglobin to a compound called methemoglobin.
    • Methemoglobin reacts with the toxic cyanide ion to form cyanomethemoglobin, which can be enzymatically degraded.

 

 

  • RELATIVE CONTRAINDICATIONS:

 

    • No contraindications for amyl nitrite in the management of cyanide poisoning.

 

 

  • SIDE EFFECTS:
    • Headache and hypotension have been  known to occur following inhalation.

 

SPECIAL NOTES / RESTRICTIONS:

 

 

  • Special Purpose Drug for TOXICOLOGY