Diltiazem

(Cardiazem)

 

INDICATIONS:

 

  • Rate Control in Refractory Atrial Fibrillation and SVT

 

ADMINISTRATION:

 

  • IV Bolus and Drip, IO

 

DOSAGE:

 

  • ADULT:

 

    • 20 mg IV/IO over 2 minutes if systolic BP ≥ 90 mmHg
    • if uncontrolled after 15 minutes from initial sode, administer 25 mg IV/IO over 2 minutes if systolic BP ≥ 90 mmHg.

 

PEDIATRIC:

 

  • NOT APPROVED

 

THERAPEUTIC EFFECTS:

 

  • The therapeutic effects of Diltiazem appear related to its ability to inhibit the influx of calcium ions during membrane depolarization of cardiac and vascular smooth muscle.
  • These effects may be seen as slowing of conduction times at the SA or AV nodes.

 

RELATIVE CONTRAINDICATIONS:

  • Concurrent or Recent use of Beta Blockers

 

SIDE EFFECTS:

  • Hypotension; Heart Block