INDICATIONS:

 

• Rate Control in Refractory Atrial Fibrillation and SVT

 

ADMINISTRATION:

 

• IV Bolus and Drip, IO

 

DOSAGE:

 

• ADULT:

 

• • 20 mg IV/IO over 2 minutes if systolic BP ≥ 90 mmHg
  • if uncontrolled after 15 minutes from initial sode, administer 25 mg IV/IO over 2 minutes if systolic BP ≥ 90 mmHg.

 

PEDIATRIC:

 

• NOT APPROVED

 

THERAPEUTIC EFFECTS:

 

• The therapeutic effects of Diltiazem appear related to its ability to inhibit the influx of calcium ions during membrane depolarization of cardiac and vascular smooth muscle.
• These effects may be seen as slowing of conduction times at the SA or AV nodes.

 

RELATIVE CONTRAINDICATIONS:

• Concurrent or Recent use of Beta Blockers

 

SIDE EFFECTS:

• Hypotension; Heart Block