Protocol Status: PUBLISHED
Protocol:
Version: 2026.01
Effective Date:
Last Reviewed:
Medical Director Approval:
Clinical Note: This content reflects current GCEMS clinical guidelines as of the dates listed above. If content appears inconsistent with current policy, use the most recent approved guideline and notify leadership for correction.

Epinephrine

(Adrenalin)

 

INDICATIONS:

 

  • Ventricular Fibrillation/Pulseless Ventricular Tachycardia
  • Asystole
  • Pulseless Electrical Activity (PEA)
  • Anaphylaxis
  • Bronchospasm

 

 DOSAGE:

 

  • ADULT:

 

    • Cardiac Arrest:

 

      • 1 mg 1:10,000 solution IV/IO every 3-5 minutes. Max 4 doses. Contact medical control to request more doses.

 

    • Anaphylactic Shock / Allergic Reaction:

 

      • ALS: If patient has respiratory distress and other signs of an allergic reaction 0.5 mg 1:1000 solution IM; may repeated every 15 minutes up to three times for a total of 4 doses.
      • Contact Medical Control if patient is
      • hemodynamically unstable, for orders of
      • 1:10,000 solution 0.05 mg to 0.1 mg IV.
      • BLS: See COG 8.3.1 for Epi pen alternative kit and dose.

 

    • Hypotension:

 

      • 10-20 mcg (1-2 ml) 1:100,000 q3-5m
      • Push Dose Epi: Mix 1 ml of Epi 1:10,000 with 9 ml NS=Epi 1:100,000.

 

  • PEDIATRIC:

 

    • Cardiac Arrest:

 

      • 0.01 mg/kg (0.1 mL/kg) 1:10,000 solution IV/IO every 3-5 minutes until ROSC

 

    • Bradycardia:

 

      • 0.01 mg/kg (0.1 mL/kg) 1:10,000 solution IV/IO every 3-5 minutes until rhythm changes or physician directs otherwise

 

    • Anaphylactic Shock / Allergic Reaction:

 

      • ALS: If patient is under 3 years of age contact Medical Control and request an order of 0.01 mg/kg 1:1,000 solution up to a max of 0.5 mg IM
      • If patient has respiratory distress and other signs of an allergic reaction; may be repeated up to three times every 15 minutes or a total of 4 doses
      • Contact Medical Control if patient is hemodynamically unstable, for orders of 1:10,000 solution 0.3 mg IV
      • BLS: See COG 8.3.1 for Epi pen alternative kit and dose.

 

    • Hypotension: Consider Push Dose EPI OLMC*

 

 

CONTRAINDICATIONS:

 

  • There are no contraindications to the use of epinephrine in the situation of cardiac arrest.

 

 SIDE EFFECTS:

 

  • Palpitations
  • Hypertension
  • Dysrhythmias
  • Anxiety
  • Tremors