Protocol Status: PUBLISHED
Protocol:
Version: 2026.01
Effective Date:
Last Reviewed:
Medical Director Approval:
Clinical Note: This content reflects current GCEMS clinical guidelines as of the dates listed above. If content appears inconsistent with current policy, use the most recent approved guideline and notify leadership for correction.

Piperacillin/Tazobactam

(Zosyn)

 

GCEMS Protocol:

 

  • Sepsis

 

Indications:

 

  • SIRS criteria x 2 and known or suspected source of infection other than pulmonary

 

Contraindications:

 

  • Allergy to to Zosyn, penicillin or their derivatives

 

Adult:

 

3.375 G ( or 4.5 G) mixed in 50 mL of NS infused IV/IO over 20 minutes

 

Peds:

 

Not approved